The Enhancing Effect of Fungal Immunomodulatory Protein-Volvariella Volvacea (FIP-vvo) on Maturation and Function of Mouse Dendritic Cells

The Enhancing Effect of Fungal Immunomodulatory Protein-Volvariella Volvacea (FIP-vvo) on Maturation and Function of Mouse Dendritic Cells

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Volvariella volvacea, also known as straw mushroom, is a common edible mushroom in Chinese cuisine.It contains many nutrients for human health.A fungal immunomodulatory protein (FIP) has caruso rhodiola been isolated from V.volvacea and named FIP-vvo.Although the regulatory effects of many FIPs on immunity have been identified, the impact of FIP-vvo in modulating dendritic cells (DCs), which play a key role to connect the innate and the adaptive immunity, is not known.

In this study, we aim to study the effect of FIP-vvo on the DC maturation and function.We found that FIP-vvo slightly increased the generation of CD11c+ bone marrow-derived DC (BMDC).In addition, the surface expression of MHCII was promoted in BMDCs after the treatment of FIP-vvo, suggesting that FIP-vvo induces DC maturation.Furthermore, FIP-vvo enhanced the ability of BMDCs to activate antigen-specific T cell responses in vitro.In the in vivo study, the FIP-vvo treatment facilitated T cell response in lymph nodes.

Therefore, for the first time, our data demonstrated that FIP-vvo promoted DC maturation and function and suggested that FIP-vvo could have benefits anodized pearl price xbox for human health by enhancing immunity.